The following case report is of a primary lung cancer with metastases to the breast and skin. This case report retrospectively analyzed the serial tumor markers cea, nes, and progrp because the diagnosis of alk rearrangementpositive nsclc in a patient. Primary malignant melanoma of the lung pmml is very rare. Interestingly, nivolumabassociated vitiligo is rarely reported in nonmelanoma malignancies. Leronlimab continues to improve health in patients with novel coronavirus. In january 2014, the patient was diagnosed as liver metastasis, which had been received hepatic. Questionnaire data from a total of 26000 case control pairs, and the biological samples from the majority of the subjects would be available.
In november 20, she underwent left lung lobectomy and systematic mediastinal lymphadenectomy and was pathologically diagnosed with adenosquamous carcinoma most are adenocarcinoma, pt1bn0m0. We report a case of an 18yearold nonsmoker female with no family history of malignancy, and no other risk factors like occupational or environmental. Molecular and biological basis of lung cancerpart i. In particular, sr of nonsmall cell lung cancer nsclc has been scarcely reported. The pathogenesis of spontaneous regressions is poorly understood, but of interest to many patients and providers. Pdf acanthosis nigricans in a patient with lung cancer. Metastatic lung cancer presenting as thoracic empyema. The main emphasis is on recent scientific developments in all. A case of small cell lung cancer treated with chemoradiotherapy. Lung cancer is the leading cause of cancerrelated death in europe and the us.
In spite of new drugs, lung cancer is associated with a very poor prognosis. It is very atypical for ism to be the initial presentation of lung cancer as well. Seven months after the diagnosis of lung cancer during the nivolumab treatment, the patient developed an. Isolated metastases to skeletal muscle and the mandible are very uncommon. Case report of a threeyear survivor with advanced nonsmall. We present the case of a 74yearold woman with advanced, poorly differentiated nsclc highly expressing programmed death ligand1 pdl1 that progressed despite multiple lines of chemotherapy but then. Lung cancer case report free download as powerpoint presentation. Thus, new drugs or reevaluation of existing therapies used to treat other nonmalignant diseases drug repurposing.
This report presented a unique and rare case of colonic metastasis of primary lung adenocarcinoma. Pdf case report leptomeningeal carcinomatosis in a. Primary lung cancer with associated empyema has been reported in lung cancer before surgery, and often it is a surprise of definitive histology, as in our case. Primary pulmonary tcell lymphoma with lung adenocarcinoma. Case 2 practical use of pdl1 testing in stage iv nsclc alexander drilon, md, outlines the case of a 58yearold, female patient with stage iv non small cell lung cancer with no actionable mutations and a pdl1 expression less than 50%, and the practical use of pdl1 testing. We present the case of a patient treated with nivolumab for advanced nsclc who was previously treated with an icp. Lung cancer is one of the leading causes of mortality in the united states, with 90% of the lung cancers being nonsmall cell lung adenocarcinoma. Spontaneous remission sr of cancer is a very rare phenomenon of unknown mechanism. Thus, expedited intestinal tract investigation should be done to allow for early detection and treatment.
However, in patients previously treated with icp inhibitors, the efficacy and safety of rechallenging the same or another icp inhibitor remain unclear. Egfr testing for metastatic nonsmall cell lung cancer with jonathan w. Spontaneous regression of nonsmall cell lung cancer. They should be a maximum of 1,500 words, contain a structured abstract and have no more than ten references. Currently, immune checkpoint icp inhibitors are essential drugs for the treatment of nonsmall cell lung cancer nsclc. It is reported that lung cancers account for 5% of second. Includes information on an unexpected association between diseases or symptoms, an unexpected event in the course of observing or treating a patient, findings that shed new light on the possible pathogenesis of the disease or an adverse effect, unique. Case report pembrolizumab is effective for a patient with extensive intracranial metastasis of nonsmall cell lung cancer poorly responsive to chemotherapy, radiotherapy, surgery and other targeting therapy. This case report suggests a new concept of cancer treatment using local destruction of cancer tissue, in this case conducted with sdt and ttf therapy, to be used in combination with serum gcmaf and colostrum maf immunotherapy as a systemic treatment. This is probably the first published case report of a patient with such long survival despite advanced disease.
There are a few cases of erythroderma in cancer patients reported in the literature. Recently, we encountered a surgical case of cavitary lung cancer whose cavity tended to enlarge during longterm followup, and was found to be lined with normal bronchial epithelium and adenocarcinoma cells. Treatment includes surgery, chemotherapy, andor radiation. Case report on stage iv lung cancer with peripheral arterial occlusive disease. Case report on lung cancer presenting with cerebral metastases and overview of treatment of lung cancer and brain metastases article pdf available june 2015 with 307 reads how we measure reads. While targeted therapies are improving outcomes, it is not uncommon for many patients to have only a partial response, and relapse during followup. In addition, only one case of tcell lymphoma and primary lung cancer overlap has been reported 6. Clinical lung cancer is devoted to articles on detection, diagnosis, prevention, and treatment of lung cancer. Lung cancer case reports list of high impact articles. The patient was eventually diagnosed with stage iv primary smallcell lung cancer. Lung cancer is the abnormal, uncontrolled growth of lung cells.
A case of small cell lung cancer treated with chemoradiotherapy followed by photodynamic therapy. Spontaneous cancer regression is rare, and particularly rare for nonsmall cell lung cancer nsclc. As lung cancer stages advance, lung cancer symptoms include coughing, wheezing, shortness of breath, and bloody mucus. Patients with breast cancer history are at risk for nonsmall cell lung cancer nsclc 2. Metastasis to the skin from lung cancer is rare and most of the time associated with an advanced neoplastic process with metastasis to other organs. The diagnosis was based on tachyzoites present in bronchoalveolar lavage and detection of. The infrequency of spontaneous regression makes it a challenging phenomenon to understand and study. Serum progrp and nse levels predicting small cell lung. Abdominal pain as initial presentation of lung cancer. Frequent sites of metastasis include the hilar lymph nodes, adrenal glands, liver, brain, and bone.
Non smallcell lung cancer with metastasis to thigh muscle. Pdf skin metastasis of lung cancercase report hakan. Acanthosis nigricans in a patient with lung cancer. Case report the patient was a 44yearold nonsmoking woman with advanced nsclc. Herein we describe a case of primary squamous cell carcinoma of the lung and concurrent sarcoma with lung metastases. Lc was the leading cause of cancer related death in males and females in the united states, and was estimated 28 % of total cancer deaths in 2010 jemal et al. Vitiligo in a patient with lung adenocarcinoma treated with nivolumab. A 48yearold african american male with a past medical history of poorly differentiated left breast cancer status after modified radical. Case reports should include relevant positive and negative findings from history, examination and investigation. Herein we report our experience with a case of metastases from lung duodenum adenocarcinoma. Three months before sclc transformation was confirmed by a liver biopsy, serum cea.
Lung cancer rarely publishes case reports but will consider unique cases or a unique series of cases of interest and relevance to the journals readership. In 2012 the most recent year numbers are available 210,828 people in the united states were diagnosed with lung cancer, including 111,395 men and 99,433 women. Reports on unusual or unexpected clinical cases that expand the field of general medical knowledge. Computed tomography ct of the patients chest illustrating a pleuralbased density in the right upper lobe measuring 3. The patient was scheduled to receive chemoradiotherapy for sclc. Hepatectomy for rapidly growing solitary liver metastasis from nonsmall cell lung cancer. The international lung cancer consortium ilcco is an international group of lung cancer researchers, established in 2004 with the aim of sharing comparable data from ongoing lung cancer case control and cohort studies. Most lung cancer types are classified by their microscopic appearance. Spontaneous regression sr is extremely rare in small cell lung cancer sclc. The present study reports a rare case of sclc accompanied by partial sr in a 68yearold man. The process by which this occurs is poorly understood.
We herein report the case of a 61yearold female patient with pmml who presented with a small nodule in the lower lobe of the left lung on chest computed tomography. Here we present a case of nivolumabassociated vitiligo in the treatment of a patient with nsclc. Metastatic nonsmall cell lung cancer with alexander drilon, md. Reports of cavitary lung cancer are not uncommon, and the cavity generally contains either dilated bronchi or cancer cells.
Ectopic cushing syndrome in small cell lung cancer. The underlying cancer is a challenging condition to diagnose. Vol 9, no 1 february 2020 translational lung cancer. Workup was remarkable for splenic mass that turns out to be adenocarcinoma with unknown primary tumour. We here describe the case of a 70yearold man who presented with asthenia, weight loss, dry cough and. Hyperprogressive disease in a patient with advanced non. An aggressive nonsmall cell lung cancer in nonsmokers. In our case, a 55yearold woman presented with a 3week history of leftsided abdominal fullness and dull pain. We present a case of a 50yearold male with a prolonged survival and a past medical history of prostate and lung cancer. Erythroderma as first manifestation of squamous cell lung. Pdf this case report highlights delay in the diagnosis of adenoma carcinoma of the lung in a female patient who has never smoked.
Chest, abdomen and back are common sites of lung cancer metastasis. Pdf lung cancer metastasis to the scapula and spine. This is caused by changes to their genetic material. Nonsmall cell lung cancer, threeyear survivor, alfafetoprotein. A case report of a threeyear survivor with advanced nonsmall cell lung cancer producing alfafetoprotein. Pdf case report on lung cancer presenting with cerebral. Shuxiang ma, zhen he, hongyong fu, lili wang, xuan wu, zhe zhang, qiming wang. Different types of lung cancers arise from different cell types within the lung. Lung cancer is one of the most common cancers in america. Case 1 concerns a 45yearold caucasian woman affected by muscle metastasis of the right thigh from nonsmallcell lung cancer. Case report second primary lung cancer after a first breast cancer.
Osimertinib achieved remarkable and sustained disease control in an advanced nonsmallcell lung cancer harboring egfr h773lv774m mutation complex author links open overlay panel minglei yang a 1 xiaoling tong b 1 xiang xu a enkuo zheng a junjun ni a junfang li a junrong yan c yang w. A rare case of nonsmall cell lung carcinoma in an 18. Computed tomography of the thorax confirmed right upper lobe mass with multiple. We report a case of a 74yearold male patient who presented with severe hypokalemia, proximal muscle weakness, peripheral edema, metabolic alkalosis, and worsening hyperglycemia. Translational lung cancer research provides practical uptodate information on prevention, early detection, diagnosis, and treatment of lung cancer. We report a case of metastatic disease to the breast from a primary lung adenocarcinoma in a young 22yearold lady. Hepatectomy for rapidly growing solitary liver metastasis. Spontaneous remission of advanced progressive poorly. Case report cavitary lung cancer lined with normal. Cureus a rare case of nonsmall cell lung cancer with.
We report the case of an 82yearold man with a lung adenocarcinoma diagnosis, who underwent immunotherapy with nivolumab as secondline treatment. Case report pembrolizumab is effective for a patient with. We present a case of biopsyproven nsclc in a 73yearold man that regressed. A 54yearold male patient with a known history of lung cancer adenocarcinoma, pt1n0m0 stage ia had been received vats wedge resection. Pdf despite the fact that nonsmallcell lung cancer nsclc is very common in the older population, these patients are frequently underrepresented in. Striking lung cancer response to selfadministration of.
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